In a cell long dsRNAs are recognized by Dicer - a member of the RNase III family of dsRNA-specific endonucleases. Cleavage of long dsRNAs by Dicer creates short dsRNAs
that are characterized by 2-nt-long 3’ overhangs. These are called small interfering RNA (siRNA) and are 21-nt-long in sequence.
Than siRNA are incorporated in protein complex called RNA induced silencing complex (RISC). After incorporation of the siRNA RISC unwind it and single stranded siRNA
that stays at RISC mediate binding to target mRNA in a sequence-specific manner. Than mRNA is cleaved by RISC. The site of the cleavage falls in the middle of the region
of siRNA complementarity. The cleaved mRNA is recognized as being aberrant and destroyed by nucleases.
siRNA as a drug
siRNA as a drug
Celon Pharma Ltd
ul. Ogrodowa 2A
05-092 Lomianki, Kielpin
ul. Ogrodowa 2A
05-092 Lomianki, Kielpin
Celon Pharma © 2009 All Rights Reserved.
Designed by GREGMAR
Designed by GREGMAR